The Effect of Berberine on the Prevention and/or Treatment on Cyclophosphamide-Induced Testicular Damage in Rats

The protective and/or therapeutic effect of berberine on cyclophosphamide-induced testicular injury was investigated in rats. A total 40 male Sprague-Dawley rats were divided into 5 groups (n=8 per group). control group received saline and CP, BER75, BER150 BER300 single dose intraperitoneal 200 mg/kg CP day 8. Berberine (75 mg/kg, 150 300 mg/kg) administered orally for 7 days before after the injection. At end protocol, testes removed histological examination, immunohistochemical staining, biochemical assessments. In our study, did not cause a significant change body weight testis weight, whereas treatment significantly decreased weight. Although no observed terms oxidative stress markers cytokine levels, degenerative changes apoptotic findings found group; which improved with increasing doses treatment. conclusion, we that may have anti-degenerative anti-apoptotic potential rather than altering inflammatory pathways CP-induced damage.